South Roxana is a village in Madison County, Illinois, United States. The population was 2,053 at the 2010 census.South Roxana is located at 38°49′35″N 90°3′32″W / 38.82639°N 90.05889°W / 38.82639; -90.05889.According to the 2010 census, South Roxana has a total area of 1.591 square miles, of which 1.52 square miles is land and 0.071 square miles is water.As of the census of 2000, there were 1,888 people, 707 households, and 518 families residing in the village. The population density was 1,190.0 people per square mile. There were 809 housing units at an average density of 509.9 per square mile. The racial makeup of the village was 97.67% White, 0.32% African American, 0.42% Native American, 0.21% Asian, 0.11% Pacific Islander, 0.32% from other races, and 0.95% from two or more races. Hispanic or Latino of any race were 0.85% of the population.There were 707 households out of which 38.0% had children under the age of 18 living with them, 53.